Publications
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Research papers in last 5 years....
Decreased Anterograde Transport Coupled with Sustained Retrograde Transport Contributes to Reduced Axonal Mitochondrial Density in Tauopathy neurons
Front. Mol. Neurosci. Sec. Brain Disease Mechanisms doi: 10.3389/fnmol.2022.927195
Findings from this study indicate that decreased kinesin-mediated transport coupled with sustained retrograde transport might reduce axonal mitochondria in tauopathy neurons, thus contributing to the synaptic deficits in Alzheimer’s Disease (AD) and other tauopathies.
Pleiotropic roles of evolutionarily conserved signaling intermediate in toll pathway (ECSIT) in pathophysiology
J Cell Physiol​, 2022 Sep;237(9):3496-3504. doi: 10.1002/jcp.30832.
This review summarizes the diverse functions of ECSIT and its involvement in pathophysiological conditions such as Alzheimer's, oxidative stress, and infection.
Broad activation of the Parkin pathway induces synaptic mitochondrial deficits in early tauopathy
Brain​, 2022 Mar 29;145(1):305-323. doi: 10.1093/brain/awab243.
In this paper we have shown new mechanistic insights into how parkin activation-enhanced Miro1 degradation and impaired mitochondrial anterograde transport drive tauopathy-linked synaptic pathogenesis and establish a foundation for future investigations into new therapeutic strategies to prevent synaptic deterioration in Alzheimer's disease and other tauopathies.
Growth hormone induces mitotic catastrophe of glomerular podocytes and contributes to proteinuria
Cell Death Dis​. 2021 Apr 1;12(4):342.doi: 10.1038/s41419-021-03643-6.
In this paper we have shown new mechanistic insights into how parkin activation-enhanced Miro1 degradation and impaired mitochondrial anterograde transport drive tauopathy-linked synaptic pathogenesis and establish a foundation for future investigations into new therapeutic strategies to prevent synaptic deterioration in Alzheimer's disease and other tauopathies.
Genetic variants in the bipolar disorder risk locus SYNE1 that affect CPG2 expression and protein function
Mol Psychiatry​ 2021 Feb;26(2):508-523. doi: 10.1038/s41380-018-0314-z. Epub 2019 Jan 4.
Impaired axonal retrograde trafficking of the retromer complex augments lysosomal deficits in Alzheimer's disease neurons
Hum Mol Genet​. 2017 Nov 15;26(22):4352-4366.doi: 10.1093/hmg/ddx321.
Releasing Syntaphilin Removes Stressed Mitochondria from Axons Independent of Mitophagy under Pathophysiological Conditions
Neuron​, 2017 May 3;94(3):595-610.e6.doi: 10.1016/j.neuron.2017.04.004.
Regulation of Synaptic Amyloid-β Generation through BACE1 Retrograde Transport in a Mouse Model of Alzheimer's Disease
J Neurosci​. 2017 Mar 8;37(10):2639-2655. doi: 10.1523/JNEUROSCI.2851-16.2017.
Impaired retrograde transport of axonal autophagosomes contributes to autophagic stress in Alzheimer's disease neurons
Elife​. 2017 Jan 13;6:e21776.doi: 10.7554/eLife.21776.
SNX-1 and RME-8 oppose the assembly of HGRS-1/ESCRT-0 degradative microdomains on endosomes
Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):E307-E316. doi: 10.1073/pnas.1612730114.
Autophagy-mediated Regulation of BACE1 Protein Trafficking and Degradation
J Biol Chem​ 2017 Feb 3;292(5):1679-1690. doi: 10.1074/jbc.M116.766584. Epub 2016 Dec 27.